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LeadScope Inc Announces Collaboration with FDA

LeadScope Inc announced that it is collaborating with the FDA under a Material Transfer Agreement (MTA). The agreement allows the FDA to use LeadScope Enterprise (both server and desktop version) for data mining and decision support. The agreement is with the Center for Drug Evaluation and Research (CDER) and the Center for Food Safety and Applied Nutrition (CFSAN).

LeadScope Enterprise is chemically intelligent decision-support software that rapidly identifies correlations between chemical structural features and any biological end-point, such as toxicity. It has been used extensively to identify toxic structural alerts.

Proprietary toxicity data can be supplemented with data from the LeadScope ToxScope database, currently containing approximately 150,000 compounds with toxicity information. These toxic alerts can then be used with LeadScope Enterprise to share this knowledge throughout an organization, helping scientists avoid potential toxic compounds earlier in the drug development process.

"The unique data-mining functionality of LeadScope software makes it an ideal tool to rapidly discover correlations between chemical structure and potential toxicity with large sets of diverse data," says Dale E. Johnson, Chief Scientific Officer of ddplatform LLC, collaborators on the ToxScope database. "It also provides chemists and toxicologists in industry and regulatory agencies the chance to test hypotheses on altering structural features of compounds under consideration for lead identification, structural optimization, or clinical development through in silico experimentation. Tools such as these have the potential to enhance drug discovery and development decisions on both sides of the regulatory interface."

Since 1997, LeadScope Inc has developed and marketed decision support tools that meet the changing needs of life scientists. The LeadScope product line includes LeadScope Enterprise, server-based decision-support software, Personal LeadScope, the desktop version of Enterprise, ToxScope, a series of toxicity databases, and soon-to-be released GeneScope, a gene expression analysis and chemical genomics system.

The expertise of LeadScope, www.leadscope.com, includes an in-depth knowledge of advanced informatics technology and the services necessary to help organizations effectively extract and visualize the valuable knowledge contained in research data. LeadScope Inc. is dedicated to working with their customers to shorten drug development time and dramatically increase the quality of research decisions.

Contact Glenn J. Myatt, Ph.D., vice president of Marketing and Business Development of LeadScope Inc, 614-675-3731, gmyatt@leadscope.com.